Generic Tadalafilo: All You Need to Know
I. the relationship between common names and trade names
1 、Define
-tadalafil gen é rico, gen é rico "means" universal "in Spanish, and tadalafil (Tadalafie) is a common name for a drug.
-some of the trade names of Tadalafie are Cialis, which is the name of the active ingredient of a drug. Different pharmaceutical companies can produce drugs under this common name, which are called generic drugs (generic drugs).
2 、Characteristics
Compared with the original drug, the generic drug of tadalafil has similar active ingredients, dosage forms, administration routes and therapeutic effects.
The advantage of generic drugs is that they may be more affordable, which helps to improve the accessibility of drugs and enable more patients to have access to treatment.
Second, pharmacological action
1 、Mechanism of action
Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor. In the treatment of male erectile dysfunction (ED), PDE5 exists mainly in corpus cavernosum smooth muscle cells and degrades cyclic guanosine monophosphate (cGMP).
Tadalafil inhibits PDE5, thereby reducing the degradation of cGMP, causing smooth muscle relaxation in the penile sponge and blood flow into the penile tissue, resulting in an erection.
2 、Effect on blood vessels
In addition to its role in the male reproductive system, tadalafil also has a certain effect on vascular endothelial function. It can improve the function of vascular endothelial cells to release vasoactive substances such as nitric oxide (NO), which is of positive significance to the cardiovascular system to some extent, but it may also bring some potential cardiovascular risks, such as the need to be cautious in combination with some cardiovascular drugs.
Indications and usage
1 、Indication
Erectile dysfunction (ED)Tadalafil is the most common indication of tadalafil, whether organic, psychological or mixed erectile dysfunction, tadalafil may effectively improve the erectile function of patients.
Pulmonary hypertension (PAH)Tadalafil can improve the exercise ability and symptoms of patients with pulmonary hypertension by dilating pulmonary vessels and reducing pulmonary artery pressure.
2 、Usage and dosage
For ED treatment:
-when taken on demand, the initial dose is recommended for 10mg, about 30 minutes-12 hours before sexual activity. Depending on the efficacy and tolerance of the individual, the dose can be increased to 20mg or reduced to 5mg.
-for patients who take it regularly once a day, the recommended dose is 2.5-5mg, taking it at about the same time every day, regardless of when to have sex.
For PAH treatmentThe generally recommended dose is 40mg, once a day.
IV. Adverse reactions and contraindications
1 、Adverse reaction
Common adverse reactions include headache, indigestion, back pain, myalgia, nasal congestion, etc. These adverse reactions are usually mild to moderate and most of them relieve themselves after withdrawal.
-A small number of patients may have abnormal vision, such as blurred vision and changes in color vision, which may be related to the inhibitory effect of tadalafil on PDE6 in the retina, but this situation is relatively rare.
2 、Contraindication
-Tadalafil is prohibited in patients who are taking any form of nitrates (such as nitroglycerin, isosorbide dinitrate, etc.) because a combination of the two can lead to severe hypotension.
-it is forbidden for people who are allergic to tadarafi.
-Tadalafil should not be used for women, children and young people under the age of 18 (except for the treatment of pulmonary hypertension, which can be used in specific pediatric patients with pulmonary hypertension under strict medical supervision).