Tadalafil vs Sildenafil for Erectile Dysfunction: Key Differences
Gui í a de Salud Masculina
Tadalafil (tadalafil) and Sildenafil (sildenafil) are both drugs used to treat male erectile dysfunction (ED). Here are some of their characteristics:
I. the mechanism of action
Identical point
Both of them belong to type 5 phosphodiesterase (PDE5) inhibitors, which reduce the degradation of cyclic guanosine monophosphate (cGMP) by inhibiting the activity of PDE5, which relaxes the smooth muscle in the penile sponge and causes blood to flow into the penile tissue, thus promoting penile erection.
Differences
Action time
Tadalafil (Tadalafe)The effect lasts for a long time, which is often called "long-acting drug", and its effective time can be as long as 36 hours, which means that patients are likely to obtain satisfactory erectile function under sexual stimulation in the longer time window after taking the drug.
Sildenafil (sildenafil)The action time is relatively short, generally about 4-6 hours, which belongs to "short-acting medicine".
II. Drug metabolism
Identical point
-both of them are mainly metabolized by cytochrome P450 enzymes (CYP450) in the liver.
Differences
Metabolic rate
Sildenafil (sildenafil)It was absorbed quickly after oral administration, and reached the peak value of plasma concentration about 1 hour after oral administration on an empty stomach, and the efficacy was faster.
Tadalafil (Tadalafe)The absorption was relatively slow and reached the peak concentration in blood about 2 hours after oral administration.
Third, dietary influence
Identical point
-A high-fat diet will affect the rate of drug absorption to some extent, but generally does not affect the final efficacy of the drug.
Differences
Influence degree
Sildenafil (sildenafil)High-fat diet has a significant effect on its absorption rate, which may delay the onset of drug action.
Tadalafil (Tadalafe)Relatively little affected by a high-fat diet.
IV. Adverse reactions
Identical point
-all may cause similar adverse reactions, such as headache, facial flush, nasal congestion, indigestion, etc., most of which are mild to moderate and usually temporary.
Differences
Occurrence probability and severity
In some clinical studies and practical applications, it has been found that tadalafil may cause relatively few adverse reactions such as visual abnormalities (such as color vision changes, blurred vision, etc.). A small number of sildenafil users reported such visual-related adverse reactions.
When using these two kinds of drugs, they should be carried out under the guidance of the doctor, and pay attention to the contraindications of the drugs, such as not being used at the same time with nitrates and so on.