Tadalafila: What You Need to Know
Guía de Salud Masculina
- 1. basic information
- 2. mechanism of action
- 3. characteristics of drugs
- 4. Dosage and Administration
- 5. Adverse reactions and contraindications
The question you want to ask may be "tadalafil".
basic information
- Tadalafil is a drug used to treat erectile dysfunction (ED) in men and can also be used to treat symptoms of benign prostatic hyperplasia (BPH).
mechanism of action
Effect on erectile dysfunction
- Tadalafil belongs to a phosphodiesterase type 5 (PDE5) inhibitor. When men are sexually stimulated, nitric oxide (NO) will be released by nerve endings and endothelial cells of the cavernous body. NO activates guanylate cyclase and increases the synthesis of cyclic guanosine monophosphate (cGMP), which leads to relaxation of the smooth muscle of the corpus cavernosum and blood flows into the corpus cavernosum, causing erection. PDE5 will degrade cGMP. Tadalafil inhibits PDE5 and increases the level of cGMP, thereby maintaining the erectile function of the penis.
Effect on benign prostatic hyperplasia
- There is PDE5 in the prostate and bladder neck. After tadalafil inhibits this enzyme, it can relax prostate smooth muscle, improve lower urinary tract symptoms (such as frequent frequency, urgency, lack of urine, etc.), and improve patients 'quality of life.
characteristics of drugs
long-term effectiveness
- Tadalafil has a long time of action, and its effective time of action can be as long as about 36 hours. Compared with some other short-acting ED treatment drugs, this feature allows patients to have more flexible sexual schedules after taking the drug without having to rush to take the drug when sexual life is approaching.
Dosage and Administration
erectile dysfunction
- When taken as needed, the recommended starting dose is 10mg, which is taken before sexual intercourse. Depending on individual efficacy and tolerability, the dose can be increased to 20mg or reduced to 5mg. The maximum frequency of medication is once a day.
- For once-daily doses, the recommended dose is 2.5mg, taken at approximately the same time every day, regardless of when to have sex.
benign prostatic hyperplasia
- The recommended dose is 5mg once daily.
Adverse reactions and contraindications
adverse reactions
- Common adverse reactions include headache, indigestion, back pain, muscle pain, nasal congestion, etc. These adverse reactions are usually mild or moderate and are generally transient.
taboo
- Patients who are taking any form of nitrate drugs (such as nitroglycerin, isosorbide dinitrate, etc.) are strictly prohibited from using tadalafil because their combination may cause severe hypotension. It is also prohibited for those who are allergic to tadalafil.