Tadalafil 5 mg (Cialis): treating ED by muscle relaxation.
Tadalafil at 5 mg is mainly used to treat erectile dysfunction (ED) in men. But you also have other indications, as follows:
1. Erectile dysfunction
Mechanism for action:
-Tadalafil inhibits the type 5 phosphodiesterase enzyme (PDE5), which is responsible for degrading nitrogen monoxide (no)-cyclic monophosphate guanosin dependent (cGMP) in the vascular smooth muscle of the penis. By inhibiting PDE5, the concentration of cGMP increases, resulting in smooth muscle relaxation and increased blood flow to the penis, facilitating erection.
Aspects of therapy:
-at a dose of 5 mg, it is considered a maintenance dose. In some men, it may be enough to improve erectile function on a continuous and predictable basis, allowing them to have spontaneous sexual intercourse. Unlike the higher doses that can be taken occasionally before sexual activity, the 5 mg dose can be taken daily in most cases.
2. Arterial pulmonary hypertension (HTAP)
Mechanism for action:
-in HTAP, tadalafil works by relaxing the vascular muscles of the pulmonary blood vessels. This reduces pulmonary blood pressure by increasing the diameter of the vessels, which facilitates blood flow through the lungs and relieves the load of the right heart that is affected by high pressure in pulmonary circulation.
Aspects of therapy:
-the dose and frequency of administration may vary according to the severity of the disease and the patient's tolerance. However, the 5 mg dose may be part of the therapeutic regimen in some cases, in combination with other measures and medications for the overall management of HTAP.
3. Other potential uses
Expansion of the phenomenon of hyperemia:
-some studies have explored the use of tadalafil at low doses (such as 5 mg) to improve microcirculation in tissues such as skeletal muscle. This is based on its generalized vasodilator effect and its ability to improve blood flow in areas where vasodilation can be beneficial, although these uses are still under investigation and are not officially approved indications for most cases.