You might want to ask about Cialis.
1. Basic information on drugs
1、pharmacological effects
- Tadalafil is a selective and reversible inhibitor of cyclic guanosine phosphate (cGMP)-specific phosphodiesterase 5 (PDE5). When sexual stimulation leads to the local release of nitric oxide, PDE5 is inhibited by tadalafil, increasing cGMP levels in the corpus cavernosum, which helps relax the smooth muscle of the corpus cavernosum and blood flow into the penile tissue, thereby creating an erection.
2、use
- It is mainly used to treat erectile dysfunction (ED) in men and, in some cases, to treat symptoms related to benign prostatic hyperplasia (BPH).
3、Dosage and Administration
- For the treatment of erectile dysfunction, the recommended starting dose is 10mg when taken as needed and taken before sexual life. Depending on the individual's efficacy and tolerance, the dose can be increased to 20mg or reduced to 5mg. The maximum frequency of medication is once a day.
- For once-daily dosing to improve erectile function, the recommended dose is 2.5mg, taken at approximately the same time every day, regardless of when to have sex.
- When treating lower urinary tract symptoms associated with benign prostatic hyperplasia, the recommended dose is 5mg once daily.
4、adverse reactions
- Common adverse reactions include headache, indigestion, back pain, myalgia, nasopharyngitis, flushing, etc. These adverse reactions are generally mild to moderate and are usually transient.
- Rare but serious adverse reactions may involve changes in vision or hearing, such as sudden vision loss (although very rare), hearing loss, etc.
5、precautions
- Patients who are taking any form of nitrates (such as nitroglycerin) should not use tadalafil because the combination of the two may cause a sharp drop in blood pressure and pose serious health risks.
- Tadalafil may enhance the antihypertensive effect of alpha-blockers, so caution should be exercised when co-administered with alpha-blockers and dose adjustments may be required.
- For patients with cardiovascular disease risk factors, appropriate assessment should be performed before using tadalafil.